Vitamin C therapy involves using high doses of vitamin C, typically administered intravenously (IV), to achieve blood concentrations not possible through oral intake. This approach is studied and applied in various medical contexts, including:

• Sepsis and Critical Illness: Reducing inflammation, oxidative stress, and organ failure.
• Cancer: Acting as an adjunct therapy, potentially enhancing chemotherapy and targeting tumor cells.
• Immunomodulation: Supporting immune function and managing conditions like colds or respiratory illnesses.

1. Fowler, A. et al.
   Date: 2019
   Journal: JAMA
   Title: “Effect of Vitamin C Infusion on Organ Failure in Sepsis”
   Summary: A randomized controlled trial found no significant reduction in organ failure with IV vitamin C in sepsis, though mortality trends suggested potential benefits.
   Key Findings: Mortality was lower in some subgroups, suggesting further research is needed.
2. Patel, V. et al.
   Date: 2021
   Journal: Critical Care Medicine
   Title: “High-Dose Vitamin C in ARDS Patients”
   Summary: This trial investigated high-dose vitamin C in ARDS patients, finding improved oxygenation but no significant change in mortality.
   Key Findings: Suggests a role in oxygenation management but not definitive for survival benefits.
3. Marik, P. et al.
   Date: 2017
   Journal: Chest
   Title: “Hydrocortisone, Vitamin C, and Thiamine in Septic Shock”
   Summary: A retrospective study showing significant reductions in mortality with this combination therapy for septic shock.
   Key Findings: Promising early results but calls for larger trials.
4. Nathens, A. et al.
   Date: 2002
   Journal: Annals of Surgery
   Title: “Vitamin C and E in Trauma Patients”
   Summary: Found lower rates of organ failure in trauma patients receiving antioxidant therapy with vitamins C and E.
   Key Findings: Suggests benefits in acute oxidative stress situations.
5. Zabet, M. et al.
   Date: 2016
   Journal: Journal of Research in Pharmacy Practice
   Title: “High-Dose Vitamin C in Sepsis”
   Summary: Randomized trial showing reduced vasopressor requirements in septic patients receiving high-dose IV vitamin C.
   Key Findings: Highlights its role in hemodynamic stabilization.
6. Chen, Q. et al.
   Date: 2005
   Journal: Proceedings of the National Academy of Sciences
   Title: “Vitamin C Induced Tumor Cytotoxicity”
   Summary: Demonstrates high-dose IV vitamin C’s potential to selectively kill cancer cells in vitro.
   Key Findings: Early-stage evidence for cancer adjunct therapy.
7. Fitzgerald, P. et al.
   Date: 2018
   Journal: Nutrients
   Title: “Vitamin C in the Common Cold”
   Summary: Meta-analysis showing reduced duration and severity of colds with regular vitamin C supplementation.
   Key Findings: Benefits seen primarily in prophylactic use.
8. Hemilä, H. et al.
   Date: 2013
   Journal: Cochrane Database of Systematic Reviews
   Title: “Vitamin C for Preventing and Treating the Common Cold”
   Summary: Examines therapeutic and preventive effects of vitamin C on colds.
   Key Findings: Preventive effects are more pronounced in high-stress populations.
9. Hoffer, L. et al.
   Date: 2015
   Journal: Clinical Nutrition
   Title: “Pharmacokinetics of High-Dose Vitamin C in Cancer Patients”
   Summary: Explores safety and pharmacokinetics of high-dose IV vitamin C in cancer.
   Key Findings: Found safe with promising plasma concentrations for adjunct therapy.
10. Cameron, E. et al.
    Date: 1979
    Journal: Proceedings of the National Academy of Sciences
    Title: “Vitamin C in Cancer Patients”
    Summary: Early observational studies indicating prolonged survival in cancer patients receiving high-dose vitamin C.
    Key Findings: Basis for modern trials.